Kidney impairment
If kidney function is reduced below a certain threshold, its ability to contribute to insulin metabolism and clearance is also reduced. This can result in the action of insulin being prolonged.

Concurrent medication
Patients who need to take steroids for any reason may also see a rise in blood glucose levels, with or without diabetes.

Steroids raise sugar levels by making the body more resistant to the effects of both natural and injected insulin. Quinine has also been reported to lower glucose levels though the mechanism is not fully understood.

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