How does insulin action change in type 2 diabetes?

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Image adapted from Study.com, CA, USA, 2016.
Type 2 diabetes occurs in adults and is typically associated with obesity and inactivity. Initially, the body is insulin resistant - this means that even though the pancreas is producing insulin, the cells in the body do not respond to it normally. It is not totally understood why this happens but it may be due to defective cellular pathways including binding of insulin to its receptor where it triggers its actions, dysfunctional signals sent from receptor binding, or due to overeating, the insulin receptors are all fully bound with insulin and so insulin