Some people may have needle phobia and as such find it difficult to administer insulin without support.

Anxiety over possible side effects from administered insulin, such as weight gain and hypoglycaemia (see side effects of insulin) may also be reasons for insulin not acting as expected.

It has also been observed that insulin based treatment in type 2 diabetes has either been delayed or doses not increased in a timely manner, due to an under appreciation of the urgent need for insulin by non specialist healthcare professionals.

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